Reviewed by Janet D. Pearl, MD, MSc
The pain of Morton neuroma is triggered by moderate physical activity (especially related to prolonged standing or running) especially after wearing shoes with narrow toe boxes. You can often alleviate the pain by taking off your shoes and manually massaging your forefoot, especially when Morton’s neuroma first appears. Surprisingly, in some cases of Morton neuroma, the pain starts abruptly in the middle of night and does not responds to conventional techniques.
Injury in the region of third and fourth metatarsal space increases the risk of developing Morton neuroma. This injury is often related to narrow shoes pressing on the  your metatarsal heads right where the medial plantar nerve and lateral plantar nerve come together to form a large bundle of nerve fibers.
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