10 Signs you may have Morton’s neuroma

Do you have foot pain or metatarsalgia? What are the 10 signs that you may have Morton’s neuroma? We specialize in treating Morton’s neuroma.

Alcohol sclerosing injections Vs Alcohol neurolytic injections

Alcohol sclerosing Vs Alcohol neurolytic injections for Morton’s neuroma We discuss the difference and importance. We specialize in treating Mortons neuroma

What shoes should I wear for Morton’s neuroma?

We are often asked what shoes should I get for my Morton’s neuroma? Shoes are critical in preventing and treating Morton’s neuroma.Our recommendations are..

What conditions mimic Morton’s neuroma?

Morton’s neuroma often mimics other musculoskeletal and neurological conditions of the foot, which makes it quite challenging to accurately diagnose.

Dextrose Prolotherapy for Morton’s neuroma?

Morton's neuroma non-surgical treatment, Morton's neuroma trends

Dextrose Prolotherapy is a new therapeutic option in Morton neuroma patients.

Where does it work?

Dextrose Prolotherapy is the injection of hypertonic dextrose to treat muscolskeletal problems. Recent studies showed that it was promising in the treatment of shoulder tendon problems(1),(2). It has also shown to be effective in knee osteoarthritis(3).

Dextrose Prolotherapy

What about Dextrose Prolotherapy for Morton’s neuroma?

Dextrose Prolotherapy has not been shown to have much effectiveness beyond joint problems such as arthritis and tendon strains.  There there has been only one study on the use of dextrose prolotherapy in Morton’s neuroma(4). The study was published in a non scientific journal and the result were poor, with only 5 out of 17 patients being able to exercise pain free after dextrose prolotherapy treatment. Given the lack of research for the use of Dextrose Prolotherapy in Morton’s neuroma, we cannot recommend it.


  1. Bertrand H, Reeves KD, Bennett CJ, Bicknell S, Cheng AL.;  Dextrose Prolotherapy versus Control Injections in Painful Rotator Cuff Tendinopathy; Arch Phys Med Rehabil. 2015 Aug 21. pii: S0003-9993(15)01091-6. doi: 10.1016/ j.apmr.2015.08.412.
  2. Lee DH, Kwack KS, Rah UW, Yoon SH.; Prolotherapy for Refractory Rotator Cuff Disease: Retrospective Case-Control Study of 1-Year Follow-Up.; Arch Phys Med Rehabil. 2015 Aug 5. pii: S0003-9993(15)00594-8. doi: 10.1016/j.apmr.2015.07.011.
  3. Rabago D, Mundt M, Zgierska A, Grettie J.; Hypertonic dextrose injection (prolotherapy) for knee osteoarthritis: Long term outcomes.; Complement Ther Med. 2015 Jun;23(3):388-95. doi: 10.1016/j.ctim.2015.04.003. Epub 2015 Apr 8.
  4. Ross A. Hauser, MD , Wayne A. Feister, DO , Debra K. Brinker,RN; Dextrose Prolotherapy Treatment for Unresolved “Morton’s Neuroma” Pain; The Foot and Ankle Online Journal, Volume 5, No. 6, June 2012

Janet D. Pearl, MD, MSc is the Medical Director of The Center for Morton’s Neuroma and Complete Spine and Pain Care, an interventional and integrated Pain Management program located in Framingham, Massachusetts. Previously, Dr. Pearl was the Co-Director of the Pain Management Center at St. Elizabeth’s Medical Center, where she was also the Director of the Fellowship program. She is the former Director of a satellite pain center of the Brigham and Women’s Hospital, Pain Management Center, located at the HealthSouth Braintree Rehabilitation Hospital. Dr. Pearl held academic appointments at Harvard Medical School and Tufts Medical School. She serves on the Health Care Services Board of the Commonwealth of Massachusetts Department of Industrial Accidents since 2000 as one of its physician representatives and is Chair of the Committee on Pain Management.

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